Code Description
e204 nBos d 6, BSA (Bovine serum albumin)
e220 nFel d 2, Cat serum albumin
e221 nCan f 3, Dog serum albumin
f67 nGal d 2, Ovalbumin
f68 nGal d 1, Ovomucoid
f69 nGal d 3, Conalbumin (Ovotransferrin)
f311 rDau c 1, Carrot
f352 rAra h 8, Peanut
f353 rGly m 4, Soya bean
f417 rApi g 1, Celery
f434 rMal d 1, Apple
g205 rPhl p 1, Timothy (Phleum pratense)
g212 rPhl p 12, Timothy (Phleum pratense)
g215 rPhl p 5b, Timothy (Phleum pratense)
t215 rBet v1, Silver birch (Betula verrucosa)
t216 rBet v 2, Silver birch (Betula verrucosa)
t220 rBet v 4, Silver birch (Betula verrucosa)
w211 rPar j 2, Wall pellitory (Parietaria judaica)
w231 nArt v1, Mugwort (Artemisia vulgaris)
w233 nArt v3, Mugwort (Artemisia vulgaris)


Significance of recombinant allergens

A selective allergy test prior to the specific immunotherapy requires the usage of highly pure allergens. In contrast to allergen extracts that contain a mixture of different allergens, recombinant allergens consist of only one protein. The usage of recombinant allergens helps to identify the protein to which specific immunoglobulines are present and cause the allergic reaction. During a specific immunotherapy (STI) a certain dosage of this pure allergen is administrated to the patient under medical supervision which barely cause symptoms (minimal dosage). This dosage is increased until habituation of immune system is achieved. STI takes 3 to 5 years and bodes a good success rate.

Recombinant allergens and native allergens

The difference between recombinant allergens and native allergens is the kind of manufacturing. To produce recombinant allergens genetically organisms are forced to assemble the allergen by themselves. The information about the allergen is transferred to the bacteria through vectors like plasmids. This plasmids carries the gene of this allergen and a reporter gene (for instance resistance to antibiotics), that helps to select those bacteria which sucessfully included plasmid. These bacteria are cultivated and recombinant allergens can be extracted from the supernatant.