The 17-OH-Progesterone ELISA kit is intended for quantitative determination of 17-OH progesterone in human serum and human plasma.
17-OH-progesterone (17-OHP) is a steroid hormone produced by suprarenal gland cortex and sex glands. The measurement of 17 OHP in serum can be used to monitor the activity of 21-hydroxylase of the suprarenal gland cortex. Deficiencies in 21-hydroxylase that are most commonly found in congenital adrenal hyperplasia result in excessive secretion of 17-OHP. However, deficiencies in 11-hydroxylase lead to moderately increase of the 17-OHP level. Therefore, the analysis of 17-OHP plays a significant role in the differential diagnostics of congenital hyperplasia of suprarenal gland cortex.
In addition, levels of 17-OHP are influenced by circadian rhythm and correlate with the adrenal secretion of cortisol. Maximal levels are found in samples collected in the morning.
|Kit volume, wells (including controls)||96|
|Analitical sensitivity, nmol/L||0.3|
|Range of evaluated concentrations, nmol/L||0.3-60|
|Incubations||30 min + 10 min at 37°Cor
30 min at 37°C + 15-30 min at RT
|Shelf life, months||12|